When running an app, you may encounter the following error:

Error

Application is damaged and can't be opened.

When attempting to reinstall the app, the error persists.

To resolve, try running the following command from a terminal:

sudo xattr -rc /Applications/Application.app

Replace Application.app with the full path of the application that has the problem.

I had this problem when installing Wineskin Winery on a Mac OS X 10.8.5. A freshly downloaded copy immediately gave the error but after adjusting the attributes on the app, it worked properly.