If your vCenter server has a self-signed certificate, you will get a warning about this when connecting to it from vSphere PowerCLI. You can disable this warning through PowerCLI with the Set-PowerCLIConfiguration cmdlet.
Set-PowerCLIConfiguration -InvalidCertificateAction Ignore
After making the change, new connections to the vCenter server will no longer produce a warning about the certificate.
You may have noticed that running the VMWare vSphere client on a display with higher DPI settings causes problems with the mouse cursor alignment when working inside a VM. This is because of a mismatch between the DPI settings of the VM and the DPI settings of your computer.
To resolve, right-click the shortcut to the client, go to the Compatibility tab, and enable Disable display scaling on high DPI settings.
The downside of this method is that there will be misalignment of some parts in the client, but it is still workable and moreover, it solves the mouse issue in a VM.
You can use the Guided Search Wizard for VMWare Compatibility Matrix to figure out if a certain version of ESX or feature is supported by a certain server or hardware platform: